Table 5.

Top five most significant prostate cancer gene set enrichment analysis (GSEA) results for six pathway databases

Database	Number of pathways queried	Bonferroni corrected p-value	Pathway	P-value for association with incident type 2 diabetes from GSEA	P-value for association with incident prostate cancer from GSEA
GO	1778	0.00003	Endosome membrane	0.160	0.004
	1778	0.00003	Ubiquitin-specific protease activity	0.237	0.014
	1778	0.00003	Mitochondrial intermembrane space	0.923	0.015
	1778	0.00003	Erythrocyte differentiation	0.752	0.015
	1778	0.00003	NAD or NADH binding	0.450	0.015
Panther	527	0.0001	Protein complex assembly	0.180	0.003
	527	0.0001	Other cell adhesion molecule	0.710	0.007
	527	0.0001	Phospholipase	0.048	0.025
	527	0.0001	Neuronal activities	0.060	0.032
	527	0.0001	Zinc finger transcription factor	0.190	0.036
Ingenuity	81	0.0006	NRF2-mediated oxidative stress response	0.648	0.049
	81	0.0006	Axonal guidance signaling	0.993	0.105
	81	0.0006	Wnt beta-catenin signaling	0.992	0.249
	81	0.0006	Nitric oxide signaling in the cardiovascular system	0.078	0.257
	81	0.0006	Leukocyte extravasation signaling	0.918	0.362
KEGG	186	0.0003	Wnt signaling pathway	0.429	0.005
	186	0.0003	Vascular smooth muscle contraction	0.033	0.033
	186	0.0003	Oocyte meiosis	0.444	0.040
	186	0.0003	Glycerophospholipid metabolism	0.061	0.049
	186	0.0003	Alpha linolenic acid metabolism	0.190	0.053
BioCarta	214	0.0002	ALK pathway	0.377	0.004
	214	0.0002	BAD pathway	0.536	0.058
	214	0.0002	GCR pathway	0.272	0.058
	214	0.0002	CREB pathway	0.026	0.058
	214	0.0002	AGPCR pathway	0.603	0.062
Reactome	430	0.0001	Transmission across chemical synapses	0.014	0.056
	430	0.0001	Prefoldin mediated transfer of substrate to CCT TRIC	0.399	0.061
	430	0.0001	Membrane trafficking	0.357	0.070
	430	0.0001	Regulation of insulin secretion by glucagon like peptide 1	0.844	0.070
	430	0.0001	Neurotransmitter receptor binding and downstream transmission in postsynaptic cell	0.003	0.111