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. Author manuscript; available in PMC: 2013 Mar 31.
Published in final edited form as: Hippocampus. 2007;17(10):943–956. doi: 10.1002/hipo.20311

FIGURE 2.

FIGURE 2

Extent of hippocampal injury after unilateral intracerebroventricular kainic acid (ICV KA) injection in young adult F344 rats. Figure compares the cytoarchitecture of an intact hippocampus (A1, A2), hippocampus ipsilateral to KA at 45 days post-administration (B1, B2), hippocampus ipsilateral to KA at 6 months post-administration (C1, C2), and hippocampus contralateral to KA at 6 months post-administration (D1, D2). Note the persistent loss of neurons in the CA3 pyramidal cell layer (denoted by asterisks) and the dentate hilus of hippocampi ipsilateral to KA administration at both 45 days and 6 months after KA administration. However, all hippocampal cell layers appear intact in hippocampus contralateral to KA administration. DG, dentate gyrus. Scale bar: A1, B1, C1, D1 = 500 μm; A2, B2, C2, D2 = 200 μm.