Skip to main content
. Author manuscript; available in PMC: 2013 Mar 31.
Published in final edited form as: Neurobiol Dis. 2007 May 23;27(2):117–132. doi: 10.1016/j.nbd.2007.03.016

Fig. 3.

Fig. 3

Location and cytoarchitecture of transplants placed into the chronically epileptic hippocampus at 4 months post-status epilepticus and analyzed at 2 months post-transplantation, visualized with 5-bromodeoxyuridine (BrdU) immunostaining (A1, B1, and C1) and Nissl staining (A2, B2, and C2). In rats receiving standard HFC grafts (A1), the overall graft area in individual sections is smaller (A1, A2) and the transplant core displayed the debris of degenerated tissue (A3). In contrast, in rats receiving grafts treated with BDNF, NT-3 and caspase inhibitor (CI) or FGF-2 and CI, graft areas in individual sections are much larger (B1, B2, C1 and C2) and transplants contain large number of surviving cells and neurons (B1–C3). DG, dentate gyrus; DH, dentate hilus. Scale bar, A1–A2, B1–B2 and C1–C2=500 µm; A3, B3 and C3=100 µm.