Figure 6.

Antitumor activity and toxicity of FL118 inTween 80-containing formulation at three scheduleson FaDu (head-&-neck) and HCT-8 (colon)-derivedtumors in animal models: The tumor model is describedin the Methods. Treatment was initiated 7days (day 0) after xenograft tumor implantation atwhich tumor size was about 200 - 250 mm³. Treatmentwith different schedules is indicated within thefigures. Individual curves are the mean tumor sizeor body weight derived from five individual tumors(5 mice per group). A. The mean tumor curves derivedfrom five individual FaDu-derived tumors onfive nude mice in response to treatment with vehicle(control), or with FL118 at its corresponding MTD usingthree schedules as shown. B. The mean tumorcurves derived from five individual HCT-8-derived tumorsin response to treatment with vehicle (control),or with FL118 at its corresponding MTD using threeschedules. C. The mean mouse body weight curvesderived from five individual mice in response to treatmentwith vehicle (control), or with FL118 at its MTDusing different schedules as shown. wk: weekly. Ofnote, the standard error (SE) for tumor size and bodyweight was not provided by SC. However, based onthe data from Table 2 and our previous experiences,body weight variation is within 20% at its MTD and,tumor size variation is usually within 30%.