Table 1.

The Maximum Tolerated Dose (MTD) of FL118 in the Tween 80-containing formulation

Schedule	Route	Mice	MTD (mg/kg/dose)
Daily x 5 (5 doses)	i.p.	Nude & SCID	≤ 0.2
q2† x 3 (3 doses)	i.p.	Nude	≤ 0.5
q2† x 5 (5 doses)	i.p.	SCID	≤ 0.4
2 day/wk x 4 (8 doses)	i.p.	Nude	≤ 0.5
Weekly x 4 (4 doses)*	i.p.	Nude & SCID	≤ 1.5

^†q2: every other day from day 0;

^*MTD for FL118 with the i.p. weekly x 4 schedule was previously reported (PLOS ONE. 2012, 7: e45571).