Table 2.

Toxicity induced by FL118 in the Tween 80-containing formulation via i.p. routes in nude and/or SCID mice

Drug	Dose (mg/kg)	Schedule (i.p.)	Mice No*	Weight loss (%)	Lethality (%)
FL118	0.30	daily x 5	5	29.0 ± 5.6	80
FL118	0.20	daily x 5	10	13.0 ± 3.7	0
FL118	0.60	q2†x 3	5	27.6 ± 13.4	80
FL118	0.50	q2†x 3	15	8.7 ± 4.9	0
FL118	0.60	q2†x 5	5	13.8 ± 3.4	20
FL118	0.40	q2†x 5	5	4.9 ± 3.5	0
FL118	0.30	q2†x 5	5	5.8 ± 5.0	0
FL118	0.75	2 days/weekly x 3	5	27.9 ± 7.6	60
FL118	0.50	2 days/weekly x 3	5	13.3 ± 4.3	0

^*Five mice were used for individual experimental groups.

Experiments where 10 mice were used, experiment repeated once, experiments where 15 mice were used, experiment repeated twice.

^†q2: every other day from day 0.