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The Maximum Tolerated Dose (MTD) of FL118 in the Tween 80-free i.v.-compatible new formulation
| Schedule | Route | Mice | MTD (mg/kg/dose) |
|---|---|---|---|
| i.v. x 1 (1 dose) | i.v. | SCID | ≥ 10 |
| Daily x 5 (5 doses) | i.v. | SCID | ≤ 1.5 |
| q2 x 5 (5 doses) | i.v. | SCID | ≤ 1.5 |
| Weekly x 4 (4 doses) | i.v. | SCID | ≤ 5.0 |
