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. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: Drug Alcohol Depend. 2012 Dec 25;129(3):226–231. doi: 10.1016/j.drugalcdep.2012.11.020

Figure 2.

Figure 2

Each adrenoceptor agonist was given at a fixed dose that produced a measurable force development. For each we show the effect of the dose on the ordinate and also show the magnitude of the increase produced by the addition of cocaine to this fixed dose of agonist. (A) is methoxamine (denuded N=5, intact N=3 at each dose). Also shown is the dose-effect curve for cocaine alone (open triangles, N=7 or greater at each dose) and it is seen that cocaine alone produces no effect for doses up to 100 µM. (B) is phenylephrine (N=7 or greater at each dose). Results are shown for aortic rings with denuded endothelium and for endothelium intact tissues.