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. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: Drug Alcohol Depend. 2012 Dec 25;129(3):226–231. doi: 10.1016/j.drugalcdep.2012.11.020

Figure 4.

Figure 4

The effect of a more extended dose range of cocaine is shown for two different cocaineagonist combinations in both endothelium denuded and intact aortic tissue, (A) phenylephrine (N=7 or greater at each dose) and (B) methoxamine (N=3 or greater at each dose). In both cases it is seen that this extended range of cocaine, in combination with the fixed dose of the adrenoceptor agent, produces relaxation at the higher cocaine doses. These U-shaped dose effect curves, presumably due to activation of a second component of action, were analyzed further and the results of that analysis are shown in Fig 5.