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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Biochim Biophys Acta. 2012 Nov 5;1834(10):2176–2186. doi: 10.1016/j.bbapap.2012.10.015

Fig. 1.

Fig. 1

The four types PDGFs and their domain compositions. The starting numbers of specific domains/segments in the coding sequences are marked above the boundaries. Shown are all numbers for human PDGFs. The proprotein convertase-recognition sequences are indicated and positions of cleavage are marked with a black triangle. Abbreviations used: SP: signal peptide; PRO: the pro-sequence preceding the growth factor domain; Cys-Knot, the cysteine-knot growth factor domain that is responsible for receptor recognition; CUB, the Complement subcomponents C1r/C1s, Urchin EGF-like protein, and Bone marrow protein 1-like domain, which can be considered as part of the pro-sequence in PDGF-C and PDGF-D, but PDGF-C and PDGF-D also have sequences homologous to the PDGF-A and PDGF-B pro-sequences.