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. 2013 Feb 19;110(13):5157–5162. doi: 10.1073/pnas.1217452110

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Fig. 5. — Analysis of in vitro data for 3D7 ring-stage parasites according to the cumulative ED model and simulation of in vivo-like responses to DHA treatment. (A) Dependence of parasite viability on the cumulative ED. The ring-stage viability data (from Fig. 3A) in the presence of QHS and DHA are plotted as a function of Ct^e/(K_m + C), which is equivalent to ED^cum/ED^max and hence proportional to ED^cum (Eq. 1). The K_m values are taken from Table 1. Symbols are as in Fig. 3A. See SI Appendix, Fig. S2 for analyses of other stages. (B) Simulation of the viability of 3D7 ring-stage parasites (blue) subjected to a DHA treatment that mimics the pharmacokinetic profile experienced in vivo. The DHA pharmacokinetic profile (C_max = 3 µM) is shown normalized in red. (C) Simulation of the influence of γ (red squares) and (blue circles) on V_res values for parasites subjected to an in vivo-like DHA pulse. The vertical dashed lines correspond to the γ (red) and (blue) values of ring-stage parasites (Table 1). The simulations in B and C were carried out as described in SI Appendix.

Inline graphic — Analysis of in vitro data for 3D7 ring-stage parasites according to the cumulative ED model and simulation of in vivo-like responses to DHA treatment. (A) Dependence of parasite viability on the cumulative ED. The ring-stage viability data (from Fig. 3A) in the presence of QHS and DHA are plotted as a function of Ct^e/(K_m + C), which is equivalent to ED^cum/ED^max and hence proportional to ED^cum (Eq. 1). The K_m values are taken from Table 1. Symbols are as in Fig. 3A. See SI Appendix, Fig. S2 for analyses of other stages. (B) Simulation of the viability of 3D7 ring-stage parasites (blue) subjected to a DHA treatment that mimics the pharmacokinetic profile experienced in vivo. The DHA pharmacokinetic profile (C_max = 3 µM) is shown normalized in red. (C) Simulation of the influence of γ (red squares) and (blue circles) on V_res values for parasites subjected to an in vivo-like DHA pulse. The vertical dashed lines correspond to the γ (red) and (blue) values of ring-stage parasites (Table 1). The simulations in B and C were carried out as described in SI Appendix.