Table 1.
Parameter estimates from analysis of viability data vs. drug concentration and length of exposure according to the cumulative ED model
| Parameter |
||||
| Drug | Stage | Km, nM |
 , h |
γ |
| QHS | hRing(2h) | 65 (6) | 0.97 (0.05) | 2.2 (0.1) |
| Ring(7.5h) | 59 (5) | 4.84 (0.05) | 6.2 (0.3) | |
| Troph(24h) | 230 (20) | 1.72 (0.05) | 5.4 (0.6) | |
| Troph(34h) | 390 (20) | 1.53 (0.04) | 5.3 (0.4) | |
| DHA | hRing(2h) | 33 (4) | 0.55 (0.05) | 2.2 (0.2) |
| Ring(7.5h) | 53 (3) | 2.08 (0.05) | 4.1 (0.2) | |
| Troph(24h) | 80 (10) | 0.53 (0.04) | 3.2 (0.3) | |
| Troph(34h) | 81 (7) | 0.68 (0.04) | 3.0 (0.2) | |
The stages and postinvasion ages of the parasites (3D7 strain) at the start of each assay are indicated. Numbers in parentheses denote SEs. Correlation coefficients between the parameter estimates are presented in SI Appendix, Table S1. Km, drug concentration resulting in half the maximum effective dose; 
, Exposure time required for 50% parasite killing at saturating drug concentrations; γ, slope of the sigmoidal function relating parasite viability and cumulative ED.