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Effects of Wwp2-deficiency on expression of various inflammatory and innate immune genes in macrophages. Wwp2+/+, Wwp2+/−, or Wwp2−/− BMDMs were treated with poly(I:C) (20 μg/mL), LPS (25 ng/mL), PGN (50 μg/mL), and R848 (40 nM) or infected with SeV for 3 h before qRT-PCR was performed (A), or the cells were treated for 18 h and then culture supernatants were collected for measurement of TNFα and IL-6 by ELISA (B). **P < 0.01; *P < 0.05 (t test).
