Table 2.

Scheme of ECG monitoring in late phase clinical trials

Level of ECG monitoring	Scheme of ECG monitoring (depending on study duration)	ECGs to be analyzed
Routine	Single ECGs in all patients at baseline, usually at steady-state and periodically thereafter when clinically indicated	Locally (assuming high quality ECG readings can be guaranteed)
Intensive	Triplicate ECGs in all patients at baseline, usually at steady-state and at least three time points thereafter (could be more in long-term studies)	Centrally