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Range of heart rate observations during the pre-therapy period and placebo and exenatide treatment. The range of observed heart rates at pre-therapy (A) and on placebo (B) treatment overlapped with the range observed on exenatide (C). 
, pre-therapy (Day −1); 
, placebo; 
, 200 pg ml−1 target exenatide concentration (Day 1); 
, 300 pg ml−1 target exenatide concentration (Day 2); 
, 500 pg ml−1 target exenatide concentration (Day 3)
