Table 1.
Slope estimates: mean of squared individual QTc-RR slopes* | |||||
---|---|---|---|---|---|
Treatment | QTcP | QTcF | QTcI | QTcPL | QTcIL |
Placebo (n = 74) | 0.0027 | 0.0028 | 0.0032 | 0.0027 | 0.0032 |
Exenatide (n = 74) | 0.0030 | 0.0031 | 0.0041 | 0.0016 | 0.0026 |
A regression line was fitted to each subject QTc/RR pairs of four replicates at 21 pre-specified ECG assessment time points (09.00 h to 15.00 h on day 1, day 2 and day 3) by treatment (exenatide or placebo) and the mean of squared individual QTc-RR slope was calculated. QTcF, Fridericia QT correction; QTcI, individual QT correction-log linear; QTcIL, individual QT correction-linear QTcP, population QT correction-log linear; QTcPL, population QT correction-linear.