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. 2012 Oct 24;34(13):982–992. doi: 10.1093/eurheartj/ehs344

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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author [2012]. For permissions please email: journals.permissions@oup.com.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.

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Effects of simvastatin on major vascular events by genotype. Proportional and absolute risk reduction are shown by genotype for loci that were significantly associated with proportional lipid response (P < 0.001). Estimates are given with 95% confidence intervals and P-values are given for the trend across genotypes. Hazard ratios and 95% CIs are plotted with box sizes weighted by the inverse-variance of the estimate. The hazard ratio in all genotyped participants is shown by a dashed line.