Table 3.

Adjusted HRs for migraine predicting depression, adjusting for various stressors, age and sex

	Model 1 (n=7339)	Model 2 (n=7339)	Model 3 (n=6840)	Model 4 (n=7121)	Model 5 (n=7176)	Model 6 (n=7144)	Model 7 (n=7127)	Model 8 (n=7339)	Model 9 (n=6387)
Migraine
Yes	1.84 (1.38–2.45)	1.55 (1.15–2.08)	1.43 (1.06–1.92)	1.46 (1.08–1.98)	1.54 (1.14–2.08)	1.51 (1.11–2.05)	1.33 (0.98–1.79)	1.46 (1.07–1.99)	1.19 (0.86–1.66)
No	Reference	Reference	Reference	Reference	Reference	Reference	Reference	Reference	Reference
Childhood trauma
None			Reference						Reference
1			1.23 (0.92–1.64)						1.14 (0.84–1.55)
2+			2.36 (1.79–3.12)						1.89 (1.38–2.59)
Recent marital status change
Yes				0.91 (0.40–2.06)					0.78 (0.33–1.84)
No				Reference					Reference
Recent Unemployed
Yes					1.52 (0.93–2.49)				1.16 (0.68–1.99)
No					Reference				Reference
Work stress
1st Quartile						Reference			Reference
2nd Quartile						0.64 (0.48–0.85)			0.70 (0.52–0.95)
3rd Quartile						0.69 (0.50–0.94)			0.76 (0.55–1.06)
4th Quartile						1.12 (0.84–1.51)			1.06 (0.77–1.48)
Chronic stress
1st Quartile							Reference		Reference
2nd Quartile							1.45 (1.06–2.00)		1.47 (1.03–2.08)
3rd Quartile							2.02 (1.50–2.73)		1.89 (1.37–2.62)
4th Quartile							2.93 (2.20–3.88)		2.49 (1.80–3.44)
Change in social support
Yes								0.91 (0.69–1.20)	0.94 (0.71–1.23)
No								Reference	Reference
Sex
Male		Reference	Reference	Reference	Reference	Reference	Reference	Reference	Reference
Female		1.91 (1.52–2.39)	1.86 (1.49–2.34)	1.94 (1.55–2.44)	1.92 (1.53–2.41)	1.80 (1.43–2.27)	1.89 (1.50–2.37)	1.89 (1.50–2.39)	1.83 (1.43–2.34)
Age (continuous)	0.98 (0.97–0.99)	0.98 (0.97–0.99)	0.98 (0.97–0.99)	0.98 (0.97–0.99)	0.98 (0.97–0.99)	0.98 (0.97–0.99)	0.98 (0.97–0.99)	0.98 (0.97–0.99)