Table 3.
Examples of mAb production in the milk of transgenic animals (TAs)
| Antibody binding antigen | Regulatory elements | TA/constructs | Maximum level of antibody production in milk, mg/ml | Reference |
|---|---|---|---|---|
| CD6-receptor | WAP-promoter (rabbit) | Mouse/two native genes | 0.4 | [90] |
| Envelope glycoprotein S (gastroenteritis coronavirus) | WAP-promoter (mouse) | Mouse/two native genes | 5 | [89] |
| Envelope glycoprotein S (gastroenteritis virus) | β-lactoglobulin promoter (sheep) | Mouse/two cDNA | 6 | [91] |
| BR96 anti-Lewis Y | β-casein promoter (goat) | Mouse/two native genes | 14 | [86] |
| BR96 anti-Lewis Y | β-casein promoter (goat) | Mouse/two native genes | 4 | [86] |
| CD20-receptor | β-casein promoter (goat) + insulator | –“– | 22.3 | [92] |
| Surface antigen (Hepatitis A virus) | β-casein promoter (goat) + insulator | –“– | 32 | [93] |
| Surface antigen (Hepatitis B virus) | –“– | –“– | 17.8 | [94] |