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. Author manuscript; available in PMC: 2014 Apr 1.
Published in final edited form as: J Neuropathol Exp Neurol. 2013 Apr;72(4):272–285. doi: 10.1097/NEN.0b013e318288a8dd

Figure 2.

Figure 2

Effect of basal forebrain cholinergic denervation (Saporin) in APP/PS1 mice on episodic memory evaluated with the new object discrimination (NOD) test. There was an overall worsening performance with age for all paradigms under study (age X transgene effect: what: [F(2,1)=12.243, ** p < 0.01), where: [F(2,1)=13.81, * p = 0.023), when: [F(2,1)=19.710, ** p < 0.01). There was significant impairment in 3-month-old (short term) lesioned mice for "what", "where" and "when" parameters (* p < 0.05 vs. Wt [WT] Sham [vehicle-treated] and WT Saporin). There was a worsening effect of cholinergic denervation in older APP/PS1 lesioned mice (7 months old) (* p < 0.05 vs. the other groups). One-way ANOVA for independent samples followed by Tukey-b or Tamahane test as needed.

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