Table.

Acetyl Cholinesterase Activity in Wild-type and APPswe/PSdE9 Mice Lesioned with Murine p75^NTR Saporin Immunotoxin

	3 months (acute)			7 months (acute)			3 months (long term)
	Cortex	Hippocampus	Striatum	Cortex	Hippocampus	Striatum	Cortex	Hippocampus	Striatum
APP/PS1 Sap	61.32±5.18**	33.75±2.80**	86.0480±8.46	61.40±5.44*	62.32±6.32**	111.7445±4.92	63.36±5.26**	55.42±7.08*	84.74±8.22
APP/PS1 Sham	95.52±8.62	87.86±3.71	100.7733±6.82	81.10±6.40	81.26±6.91	97.9884±13.36	82.65±3.93	80.,76±5.23	112.88±9.65
Wt Sap	67.49±1.91**	51.21±12.40**	92.2547±1.94	65.94±6.65*	65.83±6.97**	100.0001±6.58	60.86±6.93**	57.43±9.80*	88.67±10.20
Wt Sham	100.00±9.42	100.00±8.69	100.0072±4.51	100.00±6.90	100.00±5.02	102.8323±7.21	100.00±11.46	100.00±9.16	99.84±7.63

Data are expressed as percentage of Wt Sham values and are representative of 4–11 mice. Differences were detected with one-way ANOVA followed by Tukey-b or Tamhane tests as required. 3 months acute: Cortex [F_{(3, 16)} = 7.401, **p = 0.003 vs. Wt Sham and APP/PS1 Sham], hippocampus [F_(3,15) = 18.801, **p < 0.001 vs. Wt Sham and APP/PS1 Sham], striatum [F_{(3, 16)} = 1.12, p = 0.37]. 7 months acute: Cortex [F_{(3, 74)} = 3.43, *p = 0.021 vs. Wt Sham and APP/PS1 Sham], hippocampus [F_{(3, 71} = 7.007, **p < 0.001 vs. Wt Sham and APP/PS1 Sham], striatum [F_{(3, 80)} = 7.007, p = 0.791]. 7 months long-term; Cortex [F_{(3, 26)} = 5.126, **p = 0.006 vs. Wt Sham and APP/PS1 Sham], hippocampus [F_{(3, 38)} = 4.101, *p = 0.013 vs. Wt Sham and APP/PS1 Sham], striatum [F_{(3, 47)} = 1.73, p = 0.172].