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. 2013 Apr 1;6(2):104–111. doi: 10.1593/tlo.13127

Figure 3.

Figure 3

Systemic c-Met kinase inhibitor therapy inhibits tumor growth and depletes xenografts of stem-like cells. (A) Effects of PF2341066 (PF) on growth of Mayo 59 and Mayo 39 subcutaneous xenografts (N = 5). (B) Immunoblot analysis of phospho-(tyr-1349)- and total MET levels in control and PF-treated subcutaneous xenografts (N = 4). (C) Neurosphere formation by cells derived from control and PF-treated Mayo 59 and Mayo 39 xenografts. (D) Quantitation of neurosphere formation by cells derived from control and PF-treated xenografts (N = 4). (E) Immunoblot analysis of Nanog and Musashi expression levels in control and PF-treated Mayo 59 xenografts (N = 4). (F) Immunoblot analysis of CD133 and Sox2 expression in control and PF-treated Mayo 39 xenografts (N = 4). *P < .05, **P < .001.