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. 2013 Jan 30;121(13):2494–2502. doi: 10.1182/blood-2012-11-469122

Figure 5.

Figure 5

Helios+/− Treg numbers are not affected by antibody blocking with anti– IL-6 or anti–IL-10 in T cell–monocyte co-cultures. Relative change compared with IgG control in (A) total Treg (“Total Tregs”) as well as (B) Helios+ (“Helios+ Tregs”) and (C) Helios– (“Helios− Tregs”) Treg numbers in T cell co-cultured with total monocytes or monocyte subsets (CD14+CD16− cells without or with CD16+ monocytes) treated with neutralizing antibodies to IL-6 and IL-10 are shown. For comparison, the relative change in Treg numbers after treatment with anti–IL-12 and anti-TNF-α is also shown.