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Hypothetical model of differential regulation of Helios+/− Treg development by monocyte subsets. Interaction of T effector (Teff) with CD16− monocyte subset results in expression of TNF-α, which in turn inhibits Helios− Treg development, whereas T cell–CD16+ monocyte interactions trigger IL-12 expression, which inhibits Helios+ Treg proliferative responses.
