Table 2.
Non-compartmental analysis of MWReg30 plasma concentration-time data in C57BL/6, FcγRI/RIII(−/−), and FcγRIIb(−/−) mice
| Parametera | Group | 0.04 (mg/kg) | 0.1 (mg/kg) | 0.4(mg/kg) |
|---|---|---|---|---|
| CL (mL/day/kg) | C57BL/6 | 31.4 ± 6.0 | 37.5 ± 3.4 | 26.0 ± 4.0 |
| FcγRI/RIII (−/−) | 29.7± 1.5 | 36.0 ± 12.0 | 31.5 ± 2.0 | |
| FcγRIIb (−/−) | 30.5 ± 6.4 | 28.9 ±5.4 | NAb | |
| P-value | 0.884 | 0.308 | 0.104 | |
| AUC0–10days (nM×day) | C57BL/6 | 5.24 ± 0.68 | 12.7 ± 0.5 | 57.5 ± 3.0 |
| FcγRI/RIII (−/−) | 5.51 ± 0.24 | 13.6 ± 1.1 | 53.9 ±1.3 | |
| FcγRIIb (−/−) | 5.39 ± 1.05 | 14.5 ± 2.0 | NA | |
| P-value | 0.86 | 0.235 | 0.132 | |
| Vss (mL/kg) | C57BL/6 | 243 ± 25 | 291 ± 11 | 275 ± 23 |
| FcγRI/RIII (−/−) | 229 ± 28 | 266 ± 71 | 197 ± 50 | |
| FcγRIIb (−/−) | 244 ± 43 | 301 ± 42 | NA | |
| P-value | 0.755 | 0.594 | 0.054 |
a
Parameter values are listed as mean ± standard deviation (n=3–5). % Extrapolated AUC values were less than 25% for all strains at all dose level. P-value of <0.05 was considered significant.
b
Mice died within 24 h post MWReg30 injection.