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. Author manuscript; available in PMC: 2014 Feb 28.
Published in final edited form as: Int J Pharm. 2013 Jan 28;444(0):185–192. doi: 10.1016/j.ijpharm.2013.01.001

Table 3.

Parameter estimates for the final pharmacokinetic model

Parameter (unit) Definition Estimate %SEM
Vc (L/kg) Central volume of distribution 0.147 2.8
Vt (L/kg) Volume of tissue compartment 0.143 2.0
CLd (L/day/kg) Distribution clearance 0.101 3.9
CLc (L/day/kg) Apparent clearance 0.0343 5.6
Inter-animal Variability
  ! 2Vc Variance of inter-animal variability for Vc 0.0218 (14.8 %CV) 39.9
  ! 2CLd Variance of inter-animal variability for CLd 0.0114 (10.7 %CV) 28.2
  ! 2CLd Variance of inter-animal variability for CLc 0.208 (38.0 %CV) 76.0
Proportional residual variability
  σprop Variance of proportional residual error 0.0068 14.6

Minimum value of the objective function=−586.012