Table 2. General characteristics of the experimental groups.
| Cont. | Cont.+ RBX | DM | DM+ RBX | ZL | ZL+ RBX | ZF | ZF+ RBX | |
|---|---|---|---|---|---|---|---|---|
| number | 6 | 6 | 6 | 5 | 6 | 6 | 6 | 6 |
| After 1 week | ||||||||
| Body weight (g) | 165 ± 4 | 165±2 | 168 ± 8 | 166±1 | 188 ± 8 | 164±3 | 262± 23 | 261±12 |
| Blood glucose (mg/dl) | 98 ± 8 | 94±7 | 405±183* | 412±24* | 124 ± 9 | 100±13 | 159 ± 34 | 138±9 |
| After 8 weeks | ||||||||
| Body weight (g) | 527±45 | 541±56 | 320 ± 78* | 321±38* | 391±30 | 402±58 | 617± 23† | 621±36† |
| Blood glucose (mg/dl) | 106 ± 9 | 108±15 | 415 ± 50* | 456±66* | 114±24 | 130±16 | 157±46 | 170±49 |
| Kidney weight (g) | 2.3±0.1 | 2.2±0.2 | 3.7 ± 0.4* | 3.5±0.3* | 2.0±0.1 | 1.8±0.3 | 3.0±0.3† | 2.8±0.3 |
| Albuminuria (mg/day) | 0.2±0.1 | 0.2±0.1 | 4.7 ± 1.6* | 2.6±1.2*# | 0.1±0.1 | 0.2±0.1 | 0.6±0.3‡ | 0.4±0.2‡ |
| Insulin (ng/ml) | 2.4±0.5 | 2.5±0.4 | 0.2±0.1* | 0.2±0.1* | 2.9±0.5 | 2.8±0.4 | 42±3† | 43±5† |
Cont.=control rat, Cont.+RBX=control rat with ruboxistaurin (RBX) treatment DM=diabetic rat, DM+RBX=diabetic rat with RBX treatment, ZL=Zucker lean rat, ZL+RBX=Zucker lean rat with RBX treatment, ZF=Zucker fatty rat, ZF+RBX=Zucker fatty rat with RBX treatment.
The data are expressed as the means ± SD.
*
P<0.001 vs. Cont.;
†
P<0.001 vs. ZL;
‡
P<0.05 vs. ZL;
#
P<0.05 vs. DM