Figure 7.

CD271 levels are highest in fetal cerebellum and Shh MB and lower in more invasive and aggressive group 3 and group 4 molecular variants. (A) Data from Affymetrix exon array profiling of 14 normal cerebellar (9 fetal and 5 adult) samples (CB) and 111 primary MB presented as boxplots. CD271 expression is significantly higher in the fetal CB (***P < .001) and Shh subgroup (**P < .01) relative to the more differentiated adult cerebellar samples and significantly lower in groups 3 (*P < .05) and 4 (**P < .01). Bars denote 1.5 interquartile range within each group. (B) Working model depicting spectrum of cellular phenotypes and novel functional relationships among cells expressing CD271 and CD133.