Table 1.
Characteristics of Patients With del(11q)/del(17p) CLL: Overall and by IGHV Mutation Percentagea
| Characteristic | All Patients N = 66 | IGHV < 2% n = 50 | IGHV ≥ 2% n = 16 | P Value |
|---|---|---|---|---|
| Age at Diagnosis (Years), Median (Range) | 57.6 (26.8, 81.2) | 57.6 (26.9, 81.2) | 56.5 (30.3, 78.4) | 0.90 |
| Stage at Diagnosis, No. (%) | ||||
| Rai 0 | 21 (33) | 15 (31) | 6 (38) | < 0.99 |
| Rai 1 | 28 (44) | 21 (44) | 7 (44) | |
| Rai 2 | 10 (16) | 8 (17) | 2 (12) | |
| Rai 3 | 3 (5) | 2 (4) | 1 (6) | |
| Rai 4 | 2 (3) | 2 (4) | 0 (0) | |
| Unknown | 2 | 2 | 0 | |
| Time from Diagnosis to Initial JHU Consultation (Years), Median (Range) | 0.5 (0, 16.3) | 0.6 (0, 13.0) | 0.4 (0, 16.3) | 0.539 |
| Stage at Initial JHU Consultation, No. (%) | ||||
| Rai 0 | 20 (31) | 12 (24) | 8 (50) | .062 |
| Rai 1 | 28 (43) | 21 (43) | 7 (44) | |
| Rai 2 | 5 (8) | 5 (10) | 0 (0) | |
| Rai 3 | 2 (3) | 1 (2) | 1 (6) | |
| Rai 4 | 10 (15) | 10 (20) | 0 (0) | |
| Richter transformation | 0 (0) | 0 (0) | 0 (0) | |
| Unknown | 1 | 1 | 0 | |
| Received Treatment Before JHU Consultation | ||||
| No | 48 (73) | 33 (66) | 15 (94) | .05 |
| Yes | 18 (22) | 17 (34) | 1 (6) | |
| Time from Diagnosis to FISH (Years) - Median (Range) | 1.2 (0, 18.9) | 1.9 (0, 13.2) | 0.7 (0, 18.9) | .26 |
| Documented del(11q) - No. (%) | ||||
| No | 27 (41) | 22 (44) | 5 (31) | < .001 |
| Yes | 39 (59) | 28 (56) | 11 (69) | |
| Documented del(17p) - No. (%) | ||||
| No | 39 (59) | 28 (56) | 11 (69) | .40 |
| Yes | 27 (41) | 22 (44) | 5 (31) |
Abbreviations: IGHV = immunoglobulin heavy-chain variable; JHU = Johns Hopkins University.
a
P values for Fisher exact test or Wilcoxon rank sum tests for differences in variables between mutation groups.