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. Author manuscript; available in PMC: 2013 Jun 4.
Published in final edited form as: FEBS Lett. 2012 Apr 18;586(11):1617–1621. doi: 10.1016/j.febslet.2012.03.064

Fig. 3.

Fig. 3

Hypothetical model of ICEVchBan8 formation. (1) A fragment of an unknown mobile genetic element (shown in red) transposes into the variable region IV (VR IV) of the SXT/R391 precursor of ICEVchBan8 (shown in blue), with the same mechanism responsible for acquisition of the new genetic material in the hotspots. (2a or 2b) During transposition or in an unknown subsequent event, the 3′ region of ICEVchBan8 precursor undergoes inversion rearrangement. This inversion causes loss of the old attR site, triggering excision of the rearranged element from the prfC locus. (3) During abnormal excision, the ICE loses the 5′ region containing the original integration module (intSXT). This event may also result from competition between two integration modules in the linear or circular form. (4) Reintegration of the newborn ICEVchBan8 in VPI-2 locus is catalyzed by the new integrase (intBan8).