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. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: Leuk Lymphoma. 2011 Oct;52(10):1970–1979. doi: 10.3109/10428194.2011.582202

Figure 2.

Figure 2

A and B. Priming of PBMCs with IFN-γ and IL-15 prior to stimulation with the TLR7/8 agonist 007 significantly increases IL-12 p70 production (A) but only priming with IFN-γ significantly increases levels of IFN-α (B).

PBMC from Sezary syndrome patients were cultured with media, IFN-γ, or IL-15 for 4h followed by 20h stimulation with 007, a TLR7/8 agonist. Cytokine levels were measured in cell-free supernatants by ELISA: A. IL-12p70; B. IFN-α. Data represent mean ± standard deviation of tested individuals (n=10). ** p<0.005; * p<0.05