Top panel. Mean startle reflex responses (standardized to the distribution of responses during intertrial intervals) during standard neutral, panic attack, and survival threat as well as personal threat imagery for patients with principal panic disorder without agoraphobia, with moderate agoraphobia, and with severe agoraphobia. Bottom panel. Proportion of each group with additional (nonprincipal) fear disorders (specific and social phobias) and anxious-misery disorders (GAD, PTSD, recurrent major depression). Adapted from McTeague and colleagues.[71]