Effect of CTCE-0214 on zymosan-induced plasma TNF-α, IL-6, and IL-10 production. CD-1 mice were injected with zymosan (500 mg/kg, i.p.). One and three hours after zymosan injection, mice were injected with CTCE-0214 (25 mg/kg, i.v.). Six hours after zymosan injection, mice were injected with CTCE-0214 (25 mg/kg, i.p.). Twenty-four hours after zymosan challenge, mice were killed and plasma TNF-α (a), IL-6 (b), and IL-10 (c) were measured by ELISA. *p<0.05 compared with control; #p<0.05 compared with zymosan stimulation. N=3–6.