Table 4.
Associations of CETP polymorphisms with mean values of HDL cholesterol, CETP activity, and CETP concentration.
| Polymorphism | Genotype | N | HDL-C, mg/dL (SE) | % change | P-value | CETP activity, nmol/mL/hr (SE) | % change | P- value | CETP concentration, ug/mL (SE) | % change | P-value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| R451Q | RR | 787 | 49.7 (0.5) | 0.035 | 40.6 (0.5) | <0.001 | 1.74 (0.02) | <0.001 | |||
| RQ | 67 | 46.9 (1.7) | −5.6 | 45.9 (1.5) | +13.1 | 2.13 (0.06) | +22.4 | ||||
| 1 | 26.0 (--) | -- | 55.9 (--) | -- | 2.00 (--) | -- | |||||
| A373P | AA | 765 | 49.7 (0.5) | 0.018 | 40.6 (0.5) | 0.003 | 1.74 (0.02) | <0.001 | |||
| AP | 89 | 46.7 (1.5) | −6.0 | 44.4 (1.4) | +9.4 | 2.08 (0.06) | +19.5 | ||||
| PP | 1 | 26.0 (--) | -- | 55.8 (--) | -- | 1.99 (--) | -- | ||||
| -629C/A | CC | 199 | 47.5 (1.0) | <0.001 | 43.9 (0.9) | <0.001 | 1.97 (0.04) | <0.001 | |||
| CA | 432 | 49.0 (0.7) | +3.2 | 41.4 (0.7) | −5.7 | 1.80 (0.03) | −8.6 | ||||
| AA | 224 | 52.1 (0.9) | +9.7 | 37.5 (0.9) | −14.8 | 1.56 (0.04) | −20.8 | ||||
| Taq1B | B1B1 | 325 | 47.8 (0.8) | <0.001 | 44.0 (0.7) | <0.001 | 1.92 (0.03) | <0.001 | |||
| B1B2 | 404 | 49.8 (0.7) | +4.2 | 40.0 (0.7) | −9.1 | 1.75 (0.03) | −8.9 | ||||
| B2B2 | 126 | 53.3 (1.2) | +11.5 | 35.3 (1.1) | −19.8 | 1.44 (0.05) | −25.0 | ||||
| -2505C/A | CC | 408 | 48.2 (0.7) | 0.001 | 43.0 (0.6) | <0.001 | 1.90 (0.03) | <0.001 | |||
| CA | 352 | 50.5 (0.8) | +4.8 | 39.6 (0.7) | −7.9 | 1.68 (0.03) | −11.6 | ||||
| AA | 93 | 53.2 (1.4) | +10.4 | 35.1 (1.3) | −18.4 | 1.45 (0.05) | −23.7 |
Values are mean (standard error). No standard error was calculated (--) when 1 individual represented the group. The percentage change represents the increase (+) or decrease (−) over the baseline genotype; baseline genotypes were designated as: 451 RR, 373 AA, -629 CC, Taq1 B1B1, and -2505 CC. No percentage change was calculated (--) when 1 individual represented the group.