Table 5.

Additive genetic model associations of CETP polymorphisms with CAC, carotid plaque, and IMT.

Polymorphism	Modela		CAC presence	CAC degree	Carotid plaque presence	Common carotid IMT degree	Internal carotid IMT degree
R451Q	1	relative risk	1.27	---	1.32	---	---
		coefficient	---	0.53	---	0.01	0.11
		p-value	0.009	0.048	0.009	0.706	0.058
	2	relative risk	1.29	---	1.26	---	---
		coefficient	---	0.53	---	0.01	0.08
		p-value	0.002	0.060	0.037	0.656	0.136
	3	relative risk	1.26	---	1.26	---	---
		coefficient	---	0.51	---	0.01	0.08
		p-value	0.006	0.074	0.036	0.762	0.139
A373P	1	relative risk	1.22	---	1.23	---	---
		coefficient	---	0.42	---	0.01	0.07
		p-value	0.018	0.085	0.056	0.567	0.218
	2	relative risk	1.23	---	1.15	---	---
		coefficient	---	0.45	---	0.01	0.06
		p-value	0.007	0.078	0.238	0.642	0.285
	3	relative risk	1.21	---	1.15	---	---
		coefficient	---	0.43	---	0.01	0.05
		p-value	0.010	0.096	0.235	0.769	0.294
-629C/A	1	relative risk	0.97	---	0.95	---	---
		coefficient	---	0.02	---	−0.002	−0.02
		p-value	0.582	0.856	0.360	0.846	0.473
	2	relative risk	0.98	---	1.00	---	---
		coefficient	---	0.01	---	0.0002	0.003
		p-value	0.592	0.915	0.945	0.979	0.866
	3	relative risk	1.00	---	0.99	---	---
		coefficient	---	0.02	---	0.002	0.004
		p-value	0.951	0.875	0.928	0.767	0.824
Taq1B	1	relative risk	0.99	---	0.94	---	---
		coefficient	---	0.05	---	0.003	−0.01
		p-value	0.809	0.35	0.301	0.745	0.714
	2	relative risk	0.99	---	0.97	---	---
		coefficient	---	0.06	---	0.003	0.01
		p-value	0.800	0.630	0.589	0.724	0.643
	3	relative risk	1.02	---	0.97	---	---
		coefficient	---	0.08	---	0.01	0.01
		p-value	0.746	0.556	0.570	0.505	0.590
-2505C/A	1	relative risk	1.02	---	1.01	---	---
		coefficient	---	−0.003	---	0.002	0.02
		p-value	0.667	0.983	0.859	0.808	0.292
	2	relative risk	1.01	---	1.02	---	---
		coefficient	---	0.0004	---	0.001	0.03
		p-value	0.802	0.998	0.730	0.873	0.137
	3	relative risk	1.04	---	1.02	---	---
		coefficient	---	0.008	---	0.003	0.04
		p-value	0.425	0.954	0.737	0.665	0.114

^aModel 1: adjusted for age, gender, and race/ethnicity.

^aModel 2: adjusted for age, gender, race/ethnicity, body mass index, smoking, diabetes, hypertension, and LDL-C.

^aModel 3: adjusted for age, gender, race/ethnicity, body mass index, smoking, diabetes, hypertension, LDL-C, and HDL-C.