Skip to main content
. Author manuscript; available in PMC: 2013 Apr 13.
Published in final edited form as: Cell. 2012 Apr 13;149(2):452–466. doi: 10.1016/j.cell.2012.02.050

Figure 1. Inactivation of essential cellular pathways stimulates microbial avoidance behavior.

Figure 1

(A) Schematic of RNAi microbial aversion assay.

(B) Example of control and aversion phenotypes after 48hr of growth on elt-2 or RNAi control bacteria. elt-2 encodes a transcription factor necessary for gut development and homeostasis.

(C) Developmental stage- and rank-ordered aversion levels +SEM for 379 gene inactivations (of 4,062 screened) exhibiting aversion ≥10% off bacteria at 48-58hr of growth on RNAi bacteria.

(D) DAVID bioinformatic analysis of aversion genes showing enrichment for specific functional categories. *enriched gene classes that were not statistically significant due to small N. ^high intra-class homology that could produce an elevated false positive rate due to off-target RNAi effects.

(See also Figure S1, Table S1, Movies S1–3.)