Table 1.
Human integrin subunits and their ligands.
| Integrin | Ligand | Type of receptors |
|---|---|---|
| α5β1 | Fibronectin | RGD receptors |
| α8β1 | Fibronectin/vitronectin/nephronectin | |
| αvβ1 | Fibronectin/vitronectin | |
| αvβ3 | Vitronectin/fibronectin/fibrinogen | |
| αvβ5 | Vitronectin | |
| αvβ6 | Fibronectin | |
| αvβ8 | Vitronectin | |
| αIIbβ3 | Fibrinogen/fibronectin | |
|
| ||
| α1β1 | Collagen I/collagen IV/collagen IX | Collagen receptor |
| α2β1 | Collagen I/collagen IV/collagen IX | |
| α10β1 | Collagen II/collagen IV/collagen VI/collagen IX | |
| α11β1 | Collagen I/collagen IV/collagen IX | |
|
| ||
| α3β1 | Laminin-511/laminin-332/laminin-211 | Laminin receptor |
| α6β1 | Laminin-511/laminin-332/laminin-111/laminin-411 | |
| α6β4 | Laminin-511/laminin-332 | |
| α7β1 | Laminin-511/laminin-211/laminin-111/laminin-411 | |
|
| ||
| α4β1 | Fibronectin/VCAM-1 | Leukocyte-specific receptors |
|
α4β7 α9β1 |
MadCAM-1/fibronectin/VCAM-1 tenascin-C/VEGF-C/VEGF-D |
|
| αDβ2 | ICAM-3/VCAM-1 | |
| αLβ2 | ICAM-1/ICAM-2/ICAM-3/ICAM-5 | |
| αMβ2 | iC3b/fibronectin + more | |
| αXβ2 | iC3b/fibronectin + more | |
| αEβ7 | E-cadherin | |
RGD: arginine-glycine-aspartate, MadCAM: mucosal addressin cell adhesion molecule, ICAM: intercellular adhesion molecule, VCAM: vascular celladhesion molecule, and VEGF: vascular endothelial growth factor.