Table 2.
Renal excretory function in lean and obese SHR-corpulent rats before and after three weeks of treatment with vehicle or compound 11.
| Period | Lean SHR-cp vehicle |
Lean SHR-cp compound 11 |
Obese SHR-cp vehicle |
Obese SHR-cp compound 11 |
|
|---|---|---|---|---|---|
| Urine flow (mL/day) | Baseline | 18 ± 1 | 21 ± 2 | 57 ± 4# | 56 ± 6# |
| Week 3 | 24 ± 2 | 26 ± 3 | 46 ± 4# | 30 ± 4* | |
| Sodium excretion (mmol/day) | Baseline | 2.2 ± 0.1 | 2.3 ± 0.2 | 3.5 ± 0.2# | 3.1 ± 0.2# |
| Week 3 | 2.4 ± 0.1 | 2.0 ± 0.2 | 3.2 ± 0.3# | 2.7 ± 0.3# | |
| Potassium excretion (mmol/day) | Baseline | 5.0 ± 0.3 | 5.1 ± 0.3 | 8.4 ± 0.3# | 8.3 ± 0.3# |
| Week 3 | 5.6 ± 0.2 | 4.8 ± 0.5 | 8.0 ± 0.6# | 6.7 ± 0.4#∗ | |
| Chloride excretion (mmol/day) | Baseline | 3.7 ± 0.2 | 3.7 ± 0.3 | 5.8 ± 0.2# | 5.3 ± 0.3# |
| Week 3 | 3.7 ± 0.1 | 3.1 ± 0.3 | 5.3 ± 0.5# | 4.6 ± 0.2# | |
| Glucose excretion (mg/day) | Baseline | 7 ± 2 | 9 ± 1 | 3568 ± 391# | 3638 ± 538# |
| Week 3 | 6 ± 2 | 4 ± 1 | 1148 ± 220# | 220 ± 156#∗ | |
| Creatinine clearance (L/day) | Baseline | 6.00 ± 0.56 | 5.86 ± 0.20 | 5.47 ± 0.35 | 5.14 ± 0.20 |
| Week 3 | 6.28 ± 0.60 | 5.08 ± 0.77 | 5.95 ± 1.36 | 5.00 ± 0.23 | |
| Microalbumin excretion (mg/day) | Baseline | 2 ± 0 | 1 ± 0 | 49 ± 15# | 50 ± 22# |
| Week 3 | 5 ± 1 | 10 ± 8 | 85 ± 28# | 77 ± 28# |
Data are expressed as mean ± SEM. *P < 0.05 versus obese SHR-cp vehicle; # P < 0.05 versus lean SHR-cp.