Table 2.

Constitutive or conditional Tardbp knockout mouse models.

Investigators	Constitutive or conditional Tardbp deletion	Phenotype	Level of Tdp-43 in Tardbp+/− mice
Wu et al., Genesis 48:56, 2009	Constitutive; deleted exons 2 and 3	Peri-implantation lethality; blastocysts of homozygotes showed defective outgrowth of inner cell mass in vitro	Tardbp mRNA level similar to wild type level
Sephton et al., J. Biol. Chem. 285: 6826, 2010	Constitutive; gene trap insertion in intron 2 and inframe fusion of exon 2 with beta-galactosidase/neomycin marker	Embryonic lethality between 3.5 and 8.5 days; abnormal expansion of inner cell mass in homozygous blastocysts	mRNA and protein levels similar to those of wild types
Kraemer et al., Acta Neuropathol. 119: 409, 2010	Constitutive; gene trap insertion in intron 2 and inframe fusion of exon 2 with beta-galactosidase/neomycin marker	Embryonic lethality around day 7.5	Tdp-43 protein level similar to wild type level
Chiang et al., PNAS107: 16320, 2010	Conditional; exon 2 floxed allele	Ubiquitous deletion of Tardbp in adult mice leads to metabolic phenotype and premature death	mRNA and protein levels similar to those of wild types