Table 3.
Effect of progesterone and/or cocaine administration on plasma corticosterone (B, nmol/l), circulating progesterone (P) and 3α,5α-THP levels (nmol/l) and P and 3α,5α-THP (nmol/g) levels in the striatum and hippocampus (n=6–8 observations/grp)
| Plasma |
Striatum |
Hippocampus |
|||||
|---|---|---|---|---|---|---|---|
| B | P | 3α,5α- THP |
P | 3α,5α- THP |
P | 3α,5α- THP |
|
| ♀, Vehicle, saline |
4 ± 1 | 55 ± 9 | 30 ± 3 | 18 ± 6 | 12 ± 4 | 46 ± 10 | 37 ± 15 |
| ♀, Vehicle, cocaine |
42 ± 12 | 95 ± 15 | 52 ± 8 | 29 ± 10 | 20 ± 6 | 75 ± 10 | 64 ± 16 |
| ♀, P, saline | 2 ± 1 | 92 ± 28 | 54 ± 4 | 21 ± 8 | 20 ± 6 | 58 ± 15 | 52 ± 7 |
| ♀, P, cocaine | 32 ± 6 | 36 ± 5 | 36 ± 6 | 16 ± 9 | 13 ± 5 | 48 ± 14 | 32 ± 9 |
| ♂, Vehicle, saline |
2 ± 1 | 41 ± 3 | 20 ± 3 | 15 ± 4 | 10 ± 3 | 35 ± 9 | 26 ± 9 |
| ♂, Vehicle, cocaine |
27 ± 8 | 73 ± 12 | 45 ± 9 | 22 ± 5 | 18 ± 6 | 49 ± 15 | 36 ± 10 |
| ♂, P, saline | 1 ± 1 | 82 ± 20 | 39 ± 10 | 19 ± 6 | 14 ± 5 | 42 ± 14 | 30 ± 10 |
| ♂, P, cocaine | 21 ± 5 | 60 ± 19 | 29 ± 9 | 18 ± 6 | 12 ± 5 | 37 ± 11 | 33 ± 9 |