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. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: Sci Transl Med. 2012 Jul 25;4(144):144ra103. doi: 10.1126/scitranslmed.3003802

Fig. 1.

Fig. 1

Signaling through the mTORC1 pathway is increased in Lmna–/– mice. (A) Western blot analysis of Lmna+/+ (n = 7) and Lmna–/– (n = 8) mice heart tissue lysates. Phosphorylated mTOR(S2448), S6 kinase(T389), rpS6(S235/S236), and 4E-BP1(S65) are increased in Lmna–/– mice compared to Lmna+/+ mice. (B) Western blot analysis of Lmna+/+ (n = 7) and Lmna–/– (n = 8) mice skeletal muscle (quadriceps) tissue lysates. Phosphorylated rpS6(S235/S236) and 4E-BP1(S65) are increased in Lmna–/– mice compared to Lmna+/+ mice. However, phosphorylated S6 kinase(T389) is not significantly increased. *P < 0.05; **P < 0.01.