Fig. 3.
Treatment of Lmna–/– mice with rapamycin increases survival. (A) Kaplan-Meier plot of Lmna–/– mice (mixed 129Sv-C57BL/6J genetic background) fed control (n = 23) or diet that included encapsulated rapamycin (n = 23). Survival was significantly increased in Lmna–/– mice fed dietary rapamycin (P = 0.0013). (B) Kaplan-Meier plot of Lmna–/– mice (mixed 129Sv-C57BL/6J background) injected with vehicle (n = 11) or a higher dose of rapamycin (8 mg/kg) (n = 11). Survival was significantly increased in Lmna–/– mice injected with rapamycin (P = 0.0002).