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. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: Sci Transl Med. 2012 Jul 25;4(144):144ra103. doi: 10.1126/scitranslmed.3003802

Fig. 5.

Fig. 5

Rapamycin reduces abnormal desmin accumulation in Lmna–/– mice. (A) Desmin protein levels in heart and skeletal muscle of rapamycin-treated Lmna–/– mice (n = 6) compared to control-fed Lmna–/– mice (n = 6) as measured by Western blot analysis. (B) Accumulation of desmin in the myocytes of Lmna–/– mice compared to control Lmna+/– mice by immunohistochemistry of muscle sections. The percentage of cells with accumulation of desmin in the myocytes of Lmna–/– mice fed rapamycin (n = 4) was significantly reduced compared to Lmna–/– mice fed the control diet (n = 4). DAPI, 4′,6-diamidino-2-phenylindole. (C) Accumulation of desmin in the cardiomyocytes of Lmna–/– mice compared to control Lmna+/– mice by immunohistochemistry of heart sections. The percentage of cells with accumulation of desmin in the cardiomyocytes of Lmna–/– mice fed rapamycin (n = 4) was not different from that in Lmna–/– mice fed the control diet (n = 4). *P < 0.05.