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Systolic blood pressure in control (vehicle-treated; △), sorafenib-treated (□) and sorafenib + captopril-treated (○) rats. Rats were treated over a period of 4 weeks. Systolic blood pressure was measured by tail-cuff plethysmography. Data are the mean ± SEM (n = 6 in each group). *P < 0.05 compared with vehicle control; †P < 0.05 compared with the sorafenib-treated group (one-way ANOVA followed by Tukey’s post hoc test).
