Fig. 1.

Treatment with NBI-30775 and DMI during social stress blocked subsequent stress-induced changes in Porsolt FST behavior. a Stress/vehicle rats (solid gray bar, n=13) displayed increases in immobility indicative of a depressive-like behavioral response and a reduced incidence of swimming behaviors compared with control/vehicle (open bars, n=15) or control/NBI-30775 (hashed open bar, n=5). Interestingly, stressed rats that were treated with NBI-30775 (hashed gray bar, n=11) during the seven exposures to social stress did not exhibit stress-induced behavioral changes. b Similarly, social stress-induced increases in immobility observed in stress/vehicle rats (gray bar, n=10) as compared with control/sham (open bar, n=6) were also inhibited by prior treatment with DMI (gray hashed bar, n=10). ^ap<0.01 vs. control/vehicle, ^bp<0.05 vs. stress/vehicle, ^cp<0.05 vs. control/sham, ^dp<0.05 vs. stress/DMI