Table 1.
Effect of NBI and DMI on behavioral response to social stress and stress-induced ACTH and corticosterone
Treatment | Average defeat latency (s) | Change in upright posture (s; day 4–day 1) | ACTH (pg/ml) (day 1 post-stress) | Cort (ug/dL) (day 1 post-stress) |
---|---|---|---|---|
Stress/NBI-vehicle (n=8) | 423±41 | (−)67±50 | 316±21 | 31.5±1.5 |
Stress/NBI-30775 (n=8) | 560±38* | 96±67* | 228±27* | 16.7±2.1** |
Stress/DMI-vehicle (n=10) | 539±67 | (−)80±70 | 315±22 | 25.1±2.7 |
Stress/DMI (n=10) | 512±90 | (−)12±42 | 288±36 | 29.5±3.9 |
p<0.05;
p=0.0001; Student’s t test vs. stress/vehicle