Table 3.
Effect of NBI and DMI on resting cardiovascular parameters
Treatment | 7th day of social defeat (+ treatment)
|
24–48 h after defeat (no treatment)
|
||||
---|---|---|---|---|---|---|
SDNN | rMSSD | HR | SDNN | rMSSD | HR | |
Control/NBI-vehicle (n=7) | 5.8±0.3 | 4.7±0.1 | 363±7 | 5.7±0.5 | 5.1±0.7 | 369±5 |
Control/NBI-30775 (n=5) | 6.5±0.4 | 5.2±0.6 | 360±11 | 7.1±0.8 | 7.0±0.9* | 350±15 |
Stress/NBI-vehicle (n=15) | 4.7±0.3*,** | 4.4±0.3 | 371±7 | 4.2±0.3*,** | 4.5±0.3 | 365±5 |
Stress/NBI-30775 (n=11) | 6.2±0.6 | 5.1±0.4 | 376±8 | 6.7±0.4 | 5.3±0.3 | 366±5 |
Control/sham (n=6) | 8.0±0.5 | 6.0±0.3 | 350±12 | 6.5±0.5 | 5.3±0.3 | 370±16 |
Stress/DMI-vehicle (n=10) | 5.7±0.6*** | 5.8±0.6 | 359±7 | 5.2±0.4 | 5.7±0.4 | 367±7 |
Stress/DMI (n=10) | 5.7±0.9*** | 5.0±0.4 | 393±11****, ***** | 4.7±0.5**** | 3.9±0.5****, ***** | 414±9****,***** |
p<0.05 vs. control/NBI-vehicle;
p=0.01 vs. stress/NBI-30775;
p<0.57, one-way ANOVA;
p<0.05 vs. control/sham;
p<0.05 vs. stress/DMI-vehicle