Table 2. Summary of protein functions.
Gene | Protein Domains and Functions | Segments |
bnl | Tracheal system development; Cytokine and Heparin-binding growth factor/Fibroblast growth factor domains. | Tibia |
boi | Hedgehog pathway member with Fibronectin and Immunoglobulin domains. | Femur |
CG30371* | Possibly involved in proteolysis, and contains multiple peptidase domains. | Tibia |
CG32333* | Two domains of unknown function, DUF3657 and lipase-like DUF676. | Tibia |
CG43444 | Contains a CXXC-type zinc finger. | Femur |
CG6841 | Involved in regulation of alternative nuclear mRNA splicing, via spliceosome and in neurogenesis. | Tarsus |
CG9129* | Unknown molecular function and processes. | Tibia |
chinmo | Contains a C2H2-type zinc finger domain and BTB/POZ domain. | Tarsus |
Cka | Involved in dorsal closure and positive regulation of JNK cascade. Contains G-protein beta WD-40 repeat. | Tarsus |
CSN1b | Contains a 26S proteasome regulatory subunit. | Tarsus |
disco-r* | Contains a C2H2-type zinc finger domain. | Tarsus |
E(z) | Histone methyltransferase activity, involved in a number of developmental processes, including leg development. | Tarsus |
eIF6 | Translation initiation factor activity. | Femur |
Moe | Protein binding protein involved in a number of developmental processes, including leg development. | Femur |
mys | Epidermal growth factor protein. | Tarsus |
PI31 | Positive regulation of proteasomal ubiquitin-dependent protein catabolic process. | Femur |
Piezo* | Mechanically-gated ion channel activity. | Tibia |
sick | Involved in defense response to Gram-negative bacteria. | Femur |
Known and predicted functions of proteins were obtained from Flybase and are provided only for genes with phenocopy (boi was included because of its known redundancy with ihog). The five candidates that gave antenna-to-leg transformation with the Dll driver are marked with an asterisk.