Skip to main content
. 2013 Apr 1;8(4):e60261. doi: 10.1371/journal.pone.0060261

Table 2. Summary of protein functions.

Gene Protein Domains and Functions Segments
bnl Tracheal system development; Cytokine and Heparin-binding growth factor/Fibroblast growth factor domains. Tibia
boi Hedgehog pathway member with Fibronectin and Immunoglobulin domains. Femur
CG30371* Possibly involved in proteolysis, and contains multiple peptidase domains. Tibia
CG32333* Two domains of unknown function, DUF3657 and lipase-like DUF676. Tibia
CG43444 Contains a CXXC-type zinc finger. Femur
CG6841 Involved in regulation of alternative nuclear mRNA splicing, via spliceosome and in neurogenesis. Tarsus
CG9129* Unknown molecular function and processes. Tibia
chinmo Contains a C2H2-type zinc finger domain and BTB/POZ domain. Tarsus
Cka Involved in dorsal closure and positive regulation of JNK cascade. Contains G-protein beta WD-40 repeat. Tarsus
CSN1b Contains a 26S proteasome regulatory subunit. Tarsus
disco-r* Contains a C2H2-type zinc finger domain. Tarsus
E(z) Histone methyltransferase activity, involved in a number of developmental processes, including leg development. Tarsus
eIF6 Translation initiation factor activity. Femur
Moe Protein binding protein involved in a number of developmental processes, including leg development. Femur
mys Epidermal growth factor protein. Tarsus
PI31 Positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Femur
Piezo* Mechanically-gated ion channel activity. Tibia
sick Involved in defense response to Gram-negative bacteria. Femur

Known and predicted functions of proteins were obtained from Flybase and are provided only for genes with phenocopy (boi was included because of its known redundancy with ihog). The five candidates that gave antenna-to-leg transformation with the Dll driver are marked with an asterisk.