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. 2013 Apr 1;8(4):e59586. doi: 10.1371/journal.pone.0059586

Figure 2. Quantification of hippocampal neuronal populations in hAPP-J20 mice.

Figure 2

(A) No cell loss was detected in the CA3 region of the hippocampus of hAPP-J20 mice at 6, 24 and 36 weeks of age. (B) No cell loss in the CA1 region was detected at 6 weeks, however, 12 (p<0.05), 24 (p<0.05) and 36-week-old (p<0.001) mice showed significant cell loss when compared to aged-matched WT controls. Moreover, cell loss was significantly different between 6 and 36-week-old hAPP-J20 mice (p<0.001). Cell loss in the CA1 region can be qualitatively seen between (C) WT and (D) 36-week-old hAPP-J20 mice. Each value represents the mean ± standard error of the mean (SEM). *p<0.05, ***p<0.001.