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. 2013 Apr 1;8(4):e59586. doi: 10.1371/journal.pone.0059586

Figure 4. Quantification of CD68-positive activated microglia in hAPP-J20 mice.

Figure 4

CD68-positive microglia were observed in the hippocampus of (A) WT mice compared to (B) their hAPP-J20 littermates at 36 weeks of age. Quantification of CD68-positive cell numbers revealed significant increases in cell numbers at 24 (p<0.01) and 36 weeks of age (p<0.01) in hAPP-J20 mice compared to their age-matched WT littermates. Further, a significant increase in CD68 microglia occurred between 6 week and 36-week-old hAPP-J20 mice (p<0.01). Each value represents the mean ± standard error of the mean (SEM). **p<0.01.